Pre‑partum blood leukocyte profiles distinguish gestational inflammatory stages that predict birth‑related adverse outcomes.

ABSTRACT:

Introduction

Pregnancy is a physiological process accompanied by immuno-dynamic changes (inflammatory stages) that could influence or predict pregnancy outcomes. However, overlapping data intervals among biologically distinct conditions may hinder such differentiation. Here, a retrospective, proof-of-concept study was conducted to (a) differentiate pregnancy-related inflammatory stages, and (b) to prognosticate birth-related double risks (low birth weight and pre-term birth) based on blood tests of pregnant women.

Method

Blood samples collected from 131 Indian pregnant females (192 temporal observations) were retrospectively analyzed with: (1) a reductionist approach, which investigates cell types individually; and (2) a non-reductionist alternative, which uses a proprietary

SUBMITTER: Shankar H 

PROVIDER: S-EPMC12819648 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature