Data mining historical Chinese medical recipe collections and nuclear receptor profiling identify plant fractions that modulate glucocorticoid receptor activity.

ABSTRACT:

Objective

Glucocorticoids (GCs) play a prominent role in the management of chronic inflammatory diseases like rheumatoid arthritis and psoriatic arthritis, but their use is associated with various adverse effects. The therapeutic and adverse effects of GCs can be partly explained by modes of engagement with their target, the glucocorticoid receptor (GR). Identifying compounds that modulate GR through alternative mechanisms of action may provide a strategy to decouple therapeutic efficacy from side effects. Historical manuscripts on Chinese pharmacotherapy, which document the empirical use of natural products in treating inflammatory diseases, represent an underexplored source in drug discovery. These texts offer a historical library of plant materials and their metabolites, enablin

SUBMITTER: Prackwieser J 

PROVIDER: S-EPMC12819651 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature