Higher risk of postpartum phase transition to immune-active among HBeAg-positive pregnant women with indeterminate phase.

ABSTRACT:

Background

Understanding the natural history of hepatitis B virus (HBV) infection helps determine the optimal timing of antiviral therapy. However, a gap exists in the literature regarding the dynamics of the natural history of HBV infection in pregnant women with chronic hepatitis B (CHB). This study aimed to explore the natural history of HBV infection during pregnancy and the postpartum period.

Methods

We conducted a retrospective-prospective real-world study involving 276 pregnant women with CHB. Infection dynamics during pregnancy were characterized in 228 hepatitis B e-antigen (HBeAg)-positive and 48 HBeAg-negative participants, respectively, and during postpartum follow-up in 108 HBeAg-positive and 21 HBeAg-negative participants. HBeAg-positive participants received s

SUBMITTER: Tang Q 

PROVIDER: S-EPMC12819656 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature