Monocyte IL-1β predicts adverse cardiovascular events and associates with coronary microvascular dysfunction in kidney transplant recipients.

ABSTRACT:

Aims

Cardiovascular disease remains the leading cause of death after kidney transplantation. Coronary microvascular dysfunction (CMD) is common in kidney transplant recipients (KTRs), prognostically informative for cardiovascular events, and tightly related to inflammation. We aimed to test whether pretransplant monocytic expression of pyroptosis-related genes (IL-1β, GSDMD, Caspase-1, and NLRP3) independently predicts long-term mortality and major adverse cardiovascular events (MACE) in KTRs, and to evaluate its associations with CMD.

Methods

We enrolled 305 KTRs. Monocytes were isolated preoperatively and qPCR quantified the four genes (normalized to GAPDH). MACE included death, myocardial infarction, stroke, and heart failure. Multivariable Cox

SUBMITTER: Yin Z 

PROVIDER: S-EPMC12819680 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature