Effect of preoperative oral isomaltulose on insulin resistance and glycemic variability in patients with type 2 diabetes mellitus: a randomized controlled trial.

ABSTRACT:

Background/objectives

Preoperative oral carbohydrate alleviates postoperative insulin resistance and enhances recovery. Its utility in type 2 diabetes mellitus (T2DM) is debated due to hyperglycemia risks. Isomaltulose, a low-glycemic-index carbohydrate, has been shown to effectively attenuate postprandial glucose fluctuations and reduce metabolic stress on pancreatic β-cells in T2DM patients. This study investigated the effects of preoperative oral isomaltulose in patients with T2DM undergoing elective laparoscopic non-gastrointestinal surgery.

Methods

60 T2DM patients were randomized to receive either 300 mL of a solution containing 50 g isomaltulose (isomaltulose group) or plain water (Control group) 2-3 h preoperatively. The primary outcome was insulin resistance, assess

SUBMITTER: Wang C 

PROVIDER: S-EPMC12819711 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature