Cellular insights into transposable elements in Alzheimer's disease.

ABSTRACT:

Introduction

Alzheimer's disease (AD) is a progressive neurodegenerative disorder affecting millions worldwide. While advances in single-cell technologies have elucidated cellular diversity and transcriptional changes in AD, the contribution of transposable elements (TEs) to disease pathogenesis remains poorly understood.

Methods

We integrated published single-nucleus RNA sequencing data from 11 AD patients and 7 controls with chromatin accessibility profiles from ATAC-seq to map the cell type-specific landscape of TE expression and regulation.

Results

We identified 508 differentially expressed TE loci, 84.3% of which were upregulated in AD, indicating widespread TE activation. TE dysregulation was most prominent in excitatory neurons (319 loci) and oligodendrocytes (

SUBMITTER: Kumar V 

PROVIDER: S-EPMC12819740 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature