Clinical outcomes of aortic stenosis patients undergoing Impella-supported high-risk percutaneous coronary intervention.

ABSTRACT:

Background

Severe aortic stenosis (AS) is associated with an increased risk of adverse outcomes in patients undergoing percutaneous coronary intervention (PCI). While Impella-supported high-risk PCI (HRPCI) has demonstrated improved outcomes, its safety in patients with AS remains inadequately established.

Objectives

We evaluated the effectiveness and safety of Impella support in patients with AS undergoing HRPCI.

Methods

Patients from the PROTECT III study (NCT04136392), a single-arm, FDA-audited, multicenter investigation of Impella-supported HRPCI, were assessed. AS severity was classified as none/trivial, mild, moderate, or severe. The primary outcome was 90-day major adverse cardiac and cerebrovascular events [MACCE, defined as the composite of all-cause mortalit

SUBMITTER: Velagapudi P 

PROVIDER: S-EPMC12819752 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature