P75NTR blockading inhibits Trem2+ M1 phenotype microglia activation and myelin damage following mild traumatic brain injury.

ABSTRACT: The pathological basis underlying mild traumatic brain injury (mTBI)-induced long-term cognitive impairment is not fully understood. It is supposed that mTBI induces residential microglia activation rather than peripheral leukocyte infiltration to promote neuroinflammation, thus triggering myelin damage as well as cognitive impairment. The transformation of microglia towards a pro-inflammatory (M1 type) or anti-inflammatory (M2 type) state is critical for restraining the cerebral inflammatory response to acute or chronic insults. In addition to classical M1- and M2-like phenotypes, a specific subgroup of microglia, which is referred to as disease-associated microglia (DAM), the transition of which is regulated by triggering receptor expressed on myeloid cells 2 (Trem2), is also demonstrate

SUBMITTER: Li X 

PROVIDER: S-EPMC12819785 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature