Long-term memory in epithelia: transient IFNγ exposure drives stable repression of TFF1 in gastric epithelial cells via epigenetic changes.

ABSTRACT:

Introduction

Interferon-gamma (IFNγ) is a pro-inflammatory cytokine that is transiently produced and typically activates short-lived JAK-STAT1 signaling, yet it can also induce long-term transcriptional changes. During Helicobacter pylori infection, IFNγ persists in the gastric environment, contributing both to host defense and epithelial injury that promotes tumorigenesis. While long-term IFNγ memory has been described in immune cells, its impact on gastric epithelial reprogramming remains unclear.

Methods

We exposed gastric epithelial cells to brief IFNγ stimulation and analyzed gene expression, transcription factor involvement, and epigenetic modifications. Chromatin remodeling at the TFF1 locus was assessed through histone modification analyses, and the role of DN

SUBMITTER: Voli A 

PROVIDER: S-EPMC12819787 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature