Lower proteinuria is better for patients with IgA nephropathy: a systematic review.

ABSTRACT:

Background

Proteinuria is a well-established and recommended biomarker for disease activity in patients with IgAN. In the most recent version of the KDIGO guideline, the target level of proteinuria changed from < 1.0 g/day to < 0.5 g/day. The objective of this systematic literature review (SLR) is to identify, synthesize, and critically evaluate the evidence from peer-reviewed publications that inform the significance of achieving different proteinuria levels.

Methods

We searched PubMed and Embase (2005-2025) for studies in adult patients diagnosed with IgAN that examined the relationship between proteinuria measured by any method (e.g., uPCR, 24-hour protein excretion) and key kidney outcomes. The review used an a priori protocol following established methodological

SUBMITTER: Shah A 

PROVIDER: S-EPMC12819803 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature