Prediction of prognosis and immunotherapy response of tryptophan metabolism genes in acute myeloid leukemia.

ABSTRACT:

Background

Acute myeloid leukemia (AML) is an aggressive and heterogeneous disease, associated with significant morbidity and mortality rates. Tryptophan metabolism has been implicated in the development of several tumors. The immune landscape within the tumor microenvironment plays a pivotal role in both leukemogenesis and the determination of patient prognosis. Nonetheless, the influence of tryptophan metabolic patterns and corresponding immune signatures in AML remains largely unclear.

Methods

Transcriptomic, genomic, and clinical data from TCGA were analyzed, and GSE71014 was used for external validation. Molecular subtypes were identified via consensus clustering of tryptophan metabolism-related genes (TRPRGs). Immune infiltration was quantified using ESTIMATE. A trypto

SUBMITTER: Zhong T 

PROVIDER: S-EPMC12819808 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature