Predictive value of neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio for three-year survival in patients with early esophageal cancer undergoing endoscopic submucosal dissection.

ABSTRACT:

Background

Endoscopic submucosal dissection (ESD) has been widely applied as an effective treatment for early esophageal cancer. However, long-term prognosis after surgery remains highly variable. This study aimed to evaluate the clinical value of NLR, PLR, and MLR in patients with early esophageal cancer treated with ESD.

Methods

A total of 325 patients with early esophageal cancer who underwent ESD were retrospectively included and categorized into survival and death groups based on their three-year postoperative outcomes. Baseline characteristics between groups were compared using univariate analysis. The Cox proportional hazards model was applied to assess the associations of NLR, PLR, MLR, and their interactions with three-year survival. Restricted cubic spline (RCS) re

SUBMITTER: Zheng Y 

PROVIDER: S-EPMC12819809 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature