Study on the spatiotemporal regulation of interferon-stimulated genes during Zika virus infection.

ABSTRACT:

Background

Zika virus (ZIKV) can cause severe neurological disorders such as congenital microcephaly, and there are currently no approved prevention or treatment measures. Elucidating the antiviral mechanism of the host interferon-stimulated genes (ISGs) is crucial for the development of therapeutic strategies.

Methods

This study integrated multisystem transcriptomic data [human brain organoids, monocyte-derived dendritic cells (moDCs), and peripheral blood mononuclear cells (PBMCs) from infected patients], combined with cellular experiments and bioinformatics analysis, to systematically investigate the spatiotemporal regulation characteristics and functions of ISGs during ZIKV infection.

Results

The results showed that treatment with interferon beta (IFN-β) significa

SUBMITTER: Chen XZ 

PROVIDER: S-EPMC12819810 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature