NCOA7 promotes OSCC progression by inhibiting ROS-regulated ferroptosis.

ABSTRACT:

Background

Oral squamous cell carcinoma (OSCC) is the commonest invasive malignancy in the head and neck regions, with a worse prognosis. Recent studies revealed the role of nuclear receptor coactivator 7 (NCOA7) in promoting tumorigenesis. However, the molecular mechanism remains unclear.

Methods

Human OSCC tissues were collected and stained with H&E and NCOA7. The expression of NCOA7 in both normal and tumor tissues was compared, along with a correlation analysis with clinicopathological parameters. In vitro, NCOA7 was knocked down, and the proliferation, migration, invasion, and ferroptosis were evaluated using CCK-8, transwell and 3D spheroid migration and invasion assays, qRT-PCR, western blot, and immunocytochemistry. The effects of NCOA7 on intracellular reactive oxyg

SUBMITTER: Si H 

PROVIDER: S-EPMC12819905 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature