Modeling the dynamics of hepatic metabolism: the predominance of 12-hour rhythmicity in metabolic adaptation.

ABSTRACT:

Background and objectives

The liver continuously adjusts its metabolic activity to synchronize the nutrient supply with the body's demands. This synchronization involves the complex coordination of acute metabolic needs, nutrient availability, and activity levels, which is orchestrated according to cyclic internal rhythms governed by the circadian clock. This study aimed to decipher the role of circadian rhythms in liver metabolic functions, including mitochondrial activities that are critical for energy production and metabolic adaptation.

Methods

We investigated rhythmic changes in liver metabolism via comprehensive multiomics and kinetic mathematical modeling. The liver proteome of male mice was analyzed and modeled, and complementary serum lipidomic and metabolomic analy

SUBMITTER: Matz-Soja M 

PROVIDER: S-EPMC12819941 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature