Effectiveness and Safety of Direct Oral Anticoagulants versus Aspirin in Patients with Non-Valvular Atrial Fibrillation and Intermediate Stroke Risk.

ABSTRACT: AimsThis study compared the effectiveness and safety of direct oral anticoagulants (DOACs) versus aspirin for stroke prevention in patients with non-valvular atrial fibrillation (NVAF) and intermediate stroke risk, defined by a CHA₂DS₂-VASc score of 1 in men and 2 in women.MethodThis retrospective cohort study used Korean Health Insurance Review and Assessment Service claims data. Patients diagnosed with NVAF between January 1, 2017, and December 31, 2019, who initiated DOACs or aspirin, were included. Eligibility was restricted by CHA₂DS₂-VASc score, and patients were matched by age and sex to reduce confounding. The observation period extended until November 30, 2021. The primary outcomes were the incidence of ischemic stroke (effectiveness) an

SUBMITTER: Park S 

PROVIDER: S-EPMC12819969 | biostudies-literature | 2026 Jan-Dec

REPOSITORIES: biostudies-literature