Low-frequency activity in the subthalamic nucleus informs about the acute neuropsychiatric state in Parkinson's disease.

ABSTRACT: Sensing-guided deep brain stimulation (DBS) offers potential to further optimize symptom control in Parkinson's disease (PD) patients. Emerging evidence suggests that basal ganglia signals reflect not only motor, but also chronic neuropsychiatric symptoms. However, it remains unclear whether local field potentials (LFPs) can inform about acute neuropsychiatric states in PD, which we address in this work. Fourteen PD patients implanted with a brain-sense-enabled neurostimulator underwent an acute levodopa challenge OFF/ON stimulation one year after surgery. In each condition, resting state STN-LFPs were recorded, and the acute neuropsychiatric state was evaluated using the Neuropsychiatric Fluctuation Scale. The relationship between neuropsychiatric state and fluctuation scores with STN low

SUBMITTER: Bernasconi E 

PROVIDER: S-EPMC12820131 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature