Pan-cancer analysis reveals TREM1⁺ PMN-MDSCs as critical regulators of immune suppression and tumor microenvironment remodeling.

ABSTRACT: Polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) are crucial mediators of tumor-induced immunosuppression, while their heterogeneity and spatial dynamics across malignancies remain poorly understood. By integrating single-cell RNA sequencing data from 576 samples across 19 cancer types and spatial transcriptomics data from three distinct malignancies, we identified a PMN-MDSC population. This cell population demonstrated characteristic upregulation of immunosuppressive genes and was associated with poor prognosis across multiple cancer cohorts. Notably, TREM1 was highly expressed in PMN-MDSCs and may mediate immunosuppressive processes. Multiplex immunofluorescence demonstrated that TREM1⁺ PMN-MDSCs exhibited significantly higher distribution in tumor regions compa

SUBMITTER: Cai Y 

PROVIDER: S-EPMC12820143 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature