A metabolomic signature of maternal BMI is associated with pregnancy complications across two independent pregnancy cohorts.

ABSTRACT:

Background

Maternal obesity is increasingly common and linked to pregnancy complications, likely driven by underlying metabolic perturbations. This study investigates the association between maternal pre-pregnancy body mass index (BMI) and pregnancy complications through blood metabolomics, aiming to identify specific metabolites mediating these associations.

Methods

Data from the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) and Vitamin D Antenatal Asthma Reduction Trial (VDAART) cohorts were used, with untargeted blood metabolomics performed on blood samples taken during early-, mid-, and late gestation. Associations were assessed using multivariable logistic regression and mediation analyses to explore metabolite pathways linking maternal BMI wit

SUBMITTER: Horner D 

PROVIDER: S-EPMC12820178 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature