Breast cancer risk prediction with a modified BOADICEA model in Danish women.

ABSTRACT:

Background

Breast cancer risk prediction approaches clinical practice. The BOADICEA risk model has been updated to consider common breast cancer risk variants, lifestyle/hormonal risk factors and mammographic density (MD).

Methods

49,494 women from the Danish Blood Donor Study were followed for up to 10 years. Modified BOADICEA risks within 5 and 10 years were calculated based on a polygenic breast cancer risk score combined with lifestyle/hormonal risk factors. MD was only known for 4608 women. Calibration was assessed by comparing observed and predicted risks. AUC and Harrell's concordance index (C-index) were used to assess discriminative ability and sensitivities and specificities were obtained for high and low-risk groups.

Results

Within 5 and 10 years, 367 and 6

SUBMITTER: Novitski SI 

PROVIDER: S-EPMC12820242 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature