Natural talc: a basic, cost-effective, and available catalyst for the one-pot synthesis of dihydropyranochromenes and pyranopyrazoles, along with related DFT calculations.

ABSTRACT: This study investigates environmentally friendly and efficient protocols for synthesizing two distinct heterocyclic scaffolds: pyranopyrazoles and dihydropyranochromenes. Dihydropyranochromenes were synthesized using talc in refluxing ethanol, while pyranopyrazoles were obtained from solvent-free under mixing conditions. The advantages of these methods include high yields, operability, and the use of an accessible, inexpensive, and non-toxic basic catalyst. The reaction conditions, including reaction time, molar ratios of reactants, and catalyst amount, were optimized for the synthesis of products, resulting in high yields of 97% for pyranopyrazoles and 95% for dihydropyranochromenes. The synthesized products were characterized using analytical techniques, including FTIR and NMR, which con

SUBMITTER: Dehghanizadeh A 

PROVIDER: S-EPMC12820251 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature