Arrhythmic risk in mitral valve prolapse with mitral annular disjunction: meta-analysis of longitudinal studies.

ABSTRACT: Mitral valve prolapse (MVP) is frequently associated with mitral annular disjunction (MAD). Although numerous studies and emerging consensus suggest an arrhythmogenic role for MAD, there is a lack of large-scale meta-analyses of longitudinal studies to definitively confirm this association. We aim to evaluate the longitudinal arrhythmic risk in patients with MVP and MAD. We systematically searched PubMed, Cochrane Library, and Scopus for longitudinal studies assessing arrhythmic risk in MVP patients with MAD, from inception to May 2025. Diagnostic performance measures (sensitivity, specificity, diagnostic odds ratio, positive/negative predictive values) were pooled. Odds ratios (OR) with 95% confidence intervals (CI) were calculated using a DerSimonian and Laird random-effects model. Heter

SUBMITTER: Chianese S 

PROVIDER: S-EPMC12820290 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature