Aging Reshapes γ/δ T-Cell Immunity Through a Type I Interferon-Foxo1 Axis.

ABSTRACT: Aging is associated with profound alterations in immune cell composition and function, yet the impact on peripheral γ/δ T-cell subsets remains incompletely understood. Here, we show that the peripheral γ/δ T-cell compartment is markedly remodeled with age in mice. Specifically, innate-like Ly-6C^- CD44^hi γ/δ T cells expand in secondary lymphoid organs (SLOs) of aged mice, while adaptive-like subsets decline. This age-related shift is accompanied by enhanced functionality, with Ly-6C^- CD44^hi γ/δ T cells from aged SLOs displaying increased IL-17 production both ex vivo and in vivo following LPS challenge. Mechanistically, this functional remodeling correlates with a significant decrease in the expression of the transcription factor Foxo1 in Ly-6C

SUBMITTER: Durand A 

PROVIDER: S-EPMC12820350 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature