Investigating the mechanisms of lactulose on gut health and uric acid metabolism in geese via transcriptomics.

ABSTRACT: In recent years, the escalating incidence of goose gout has inflicted severe economic losses on the goose industry. This research aimed to investigate the impact of lactulose on both intestinal health and uric acid metabolism in geese, as well as to elucidate its possible mechanisms through RNA-seq analysis. A total of 180 one-day-old Yangzhou geese were assigned to three different groups: the control group (CG), which received a standard diet; the high-protein model group (MG), which was provided a diet with 21% crude protein; and the lactulose group (LS), which had a diet containing 21% crude protein along with 0.3% lactulose. The findings indicated that the LS group exhibited significantly reduced serum uric acid levels and an intact ileal mucosal structure when compared to both the CG

SUBMITTER: Ye P 

PROVIDER: S-EPMC12820359 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature