In tendons, differing physiological requirements lead to distinct patterns of MMP-1 degradation.

ABSTRACT: Collagen fibrils from high-stress, energy-storing tendons critical to locomotion are smaller in diameter with increased intermolecular crosslinking compared to fibrils from low-stress, positional tendons. This results in distinct loading mechanics thought to limit fatigue damage in energy-storing tendons. However, there appears to be a functional trade-off with energy-storing tendons also having reduced remodeling ability. Energy-storing tendons have lower collagen turnover and increased injury rates compared to positional tendons. In a recent study, a causative factor for this lower collagen turnover was suggested: resistance to degradation by MMP-1. To validate the prior study's results obtained from single fibrils, the current study undertook population level assessment of fibril degrad

SUBMITTER: Gsell KY 

PROVIDER: S-EPMC12820382 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature