Predicting Invasiveness of Lung Adenocarcinoma from Chest CT with Few-shot Vision-Language Ternary Classification Model.

ABSTRACT: Preoperative differentiation of preinvasive lesions, minimally invasive adenocarcinomas, and invasive adenocarcinomas within pure ground-glass nodules (pGGNs) is challenging. Herein, this study investigated the potential of vision-language models to assist radiologists in noninvasively predicting pGGN invasiveness on CT scans. This retrospective multicenter study enrolled 848 patients with pathologically-confirmed lung adenocarcinoma manifesting as pGGNs. GPT-4o was tasked with localizing pGGNs on CT scans to detect ten pGGN invasiveness-associated features to generate a diagnosis and was compared with Molmo. The twenty-shot GPT-4o model demonstrated superior performance in the ternary classification of pGGN invasiveness (Delong test, P < 0.01). Six radiologists' assessments revealed that

SUBMITTER: Xu N 

PROVIDER: S-EPMC12820389 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature