Analytic Fourier ptychotomography for aberration-free and high-resolution volumetric refractive index imaging.

ABSTRACT: Three-dimensional (3D) refractive index tomography offers label-free quantitative volumetric imaging. However, existing tomography approaches are limited by optical aberrations, limited resolution, and computational complexity. To overcome these issues, we propose Analytic Fourier Ptychotomography (AFP), a computational microscopy technique that analytically reconstructs aberration-free, complex-valued 3D refractive index distributions without iterative optimization or axial scanning. AFP employs a unique prior based on the finite sample thickness to recast the inverse scattering problem into analytically solvable linear equations. Unlike iterative methods, AFP does not require parameter tuning and computationally intensive optimizations, and can achieve efficient, robust, and generalizabl

SUBMITTER: Dong Z 

PROVIDER: S-EPMC12820392 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature