Impact of Neuromuscular Electrical Stimulation on Biological Markers in Critically Ill Patients: A Systematic Review and Meta-Analysis.

ABSTRACT:

Purpose

Neuromuscular electrical stimulation (NMES) has been increasingly used to preserve or restore neuromuscular function in critically ill patients. However, its effects on inflammatory biomarkers and its safety require to be fully elucidated. This study aimed to analyze the available evidence on the impact of NMES on biological markers in critically ill patients.

Methods

This systematic review followed a preregistered protocol (PROSPERO: CRD42023424413). A comprehensive search was conducted in PubMed, EMBASE, Web of Science, Scopus, PEDro, CENTRAL, and Google Scholar to identify randomized controlled trials (RCTs) comparing NMES with control interventions and reporting outcomes related to biological markers.

Results

Ten RCTs were included in this review. Meta-ana

SUBMITTER: Santos AO 

PROVIDER: S-EPMC12820417 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature