Maternal Autoimmune Disease and Childhood-Onset Type 1 Diabetes: A Nationwide Population-Based Nested Case-Control Study.

ABSTRACT:

Introduction

Type 1 diabetes mellitus (T1DM) is an autoimmune disease that damages insulin-producing pancreatic cells, often appearing in childhood. Global incidence is rising at 2%-3% yearly. Its exact cause is unclear. Prenatal exposures and maternal autoimmune disorders have been reported as potential risk factors. This study aimed to explore how maternal autoimmune conditions might correlate with the onset of T1DM, employing a population-focused approach.

Methods

This is a retrospective population-based cohort study with a nested case-control analysis. Primary data were derived from the Maternal and Child Health Database (MCHD) and the National Health Insurance Research Database (NHIRD). This study enrolled a total of 2,036,051 newborns born between 2004 and 2014. They w

SUBMITTER: Yen HC 

PROVIDER: S-EPMC12820419 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature