Activity of novel antibiotics against dual metallo-Beta-lactamase producing Enterobacter hormaechei clinical isolates.

ABSTRACT:

Background

Metallo-β-lactamase (MBL)-producing carbapenemase-resistant Enterobacterales infections are associated with significant mortality. Several β-lactam/β-lactamase inhibitor combinations (BL/BLI) with promising activity against MBLs are in the pipeline.

Objective

To investigate the in vitro activity of upcoming BL/BLI agents against Enterobacter hormaechei clinical isolates co-producing NDM and VIM enzymes.

Methods

Eleven E. hormaechei isolates co-harbouring bla _NDM-7 and bla _VIM-1 were identified from 10 patients admitted to a tertiary hospital in Santiago, Chile, between July 2022 and July 2023. Reference broth microdilution (BMD) panels were developed to determine minimum inhibitory concentrations (MIC

SUBMITTER: Solar C 

PROVIDER: S-EPMC12820428 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature