Biofluid-based predictors of post-concussion symptoms: a narrative review of mild traumatic brain injury biomarkers.

ABSTRACT: Mild traumatic brain injury can disrupt brain function and is associated with high morbidity and healthcare utilization. While many individuals recover from mild traumatic brain injury, a significant proportion experience long-term sequelae, collectively known as post-concussion syndrome. Symptoms of post-concussion syndrome include headache, dizziness, insomnia, cognitive processing difficulties and mental health disturbances. The disease burden is augmented by the current lack of objective measures to accurately predict long-term symptoms and deficits, providing an opportunity to utilize biomarkers in biofluids. A large proportion of available diagnostic clinical tools are subjective symptom scores. This review aims to explore current fluid biomarkers, grouped by clinical symptoms. With

SUBMITTER: Lyons HS 

PROVIDER: S-EPMC12820430 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature