Two distinct durable human class-switched memory B cell populations are induced by vaccination and infection.

ABSTRACT: Memory lymphocytes are durable cells that persist in the absence of antigen, but few human B cell subsets have been characterized in terms of durability. The relative durability of eight non-overlapping human B cell sub-populations covering 100% of all human class-switched B cells was interrogated. Only two long-lived B cell populations persisted in the relative absence of antigen. In addition to canonical germinal center-derived switched-memory B cells with an IgD^-CD27⁺CXCR5⁺ phenotype, a second, non-canonical, but distinct memory population of IgD^-CD27^-CXCR5⁺ DN1 B cells was also durable, exhibited a unique TP63-linked transcriptional and anti-apoptotic signature, had low levels of somatic hypermutation, but was more clona

SUBMITTER: Perugino CA 

PROVIDER: S-EPMC12820432 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature