Major Depressive Disorder With Versus Without Psychosocial Triggers: A Secondary Analysis of a Prospective Cohort Study.

ABSTRACT:

Background

Few studies have examined differences in symptom presentation and antidepressant response between patients with major depressive disorder (MDD) with and without psychosocial triggers.

Methods

This was a secondary analysis of a multicenter, multistage prospective cohort study conducted at nine top tertiary hospitals across six provinces/municipalities in China. The cohort included patients with first-episode MDD, with or without psychosocial triggers, who received one of six selective serotonin reuptake inhibitors (SSRIs).

Results

Of 359 enrolled patients with first-episode MDD, 303 (mean [SD] age, 39.6 [10.1] years; 201 [66.8%] women) were included in the final analysis. There were no significant differences in network structure (M = 0.40; p =

SUBMITTER: Xiao C 

PROVIDER: S-EPMC12820511 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature