Delayed Duodenal Ulcer Perforation Following Esophageal Endoscopic Submucosal Dissection Complicated by Perforation: A Case Report.

ABSTRACT: Endoscopic submucosal dissection (ESD) is an established treatment of superficial esophageal neoplasms. Common complications include bleeding, perforation, and stricture. However, delayed gastrointestinal perforation distant from the ESD site is exceptionally rare. We report the case of a woman in her 70s with a history of nonsteroidal anti-inflammatory drug (NSAID)-associated duodenal ulcer and Helicobacter pylori infection who underwent ESD for superficial esophageal squamous cell carcinoma. After eradication therapy and 2 months of proton pump inhibitor (PPI) use, both treatments were discontinued. Preoperative endoscopy confirmed a scarred duodenal ulcer. Intraoperative esophageal perforation occurred during ESD and was closed with clips. Postoperative computed tomography (CT) s

SUBMITTER: Nakatani S 

PROVIDER: S-EPMC12820514 | biostudies-literature | 2026 Apr

REPOSITORIES: biostudies-literature