YhfH functions as a tri-function RNA in Bacillus thuringiensis BMB171.

ABSTRACT: Regulatory RNAs are crucial for transcriptional and posttranscriptional regulation in bacteria and hold significant potential as tools for gene expression in synthetic biology. In our previous study, YhfH in the Bacillus thuringiensis BMB171 strain was identified as a regulatory RNA that functions as an antisense RNA to modulate the expression of LipR, a transcriptional regulator involved in intracellular pH regulation in glucose-rich environments. This study further reveals that YhfH, predominantly expressed during the stationary phase, acts as a small RNA (sRNA) to regulate the expression of the pyrimidine biosynthetic operon, thereby influencing the bacterial growth in pyrimidine-limited media. Additionally, YhfH RNA serves as a messenger RNA (mRNA) encoding a peptide, YhfH-P, which inh

SUBMITTER: Qin J 

PROVIDER: S-EPMC12820528 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature