Genetic Determinants of Hematopoietic Toxicity Risk in Thai Pediatric Patients Undergoing 6-Mercaptopurine Treatment.

ABSTRACT: The nucleoside diphosphate-linked moiety X-type motif 15 (NUDT15) has been identified as a key genetic determinant of 6-mercaptopurine (6-MP)-induced hematopoietic toxicity in populations with a high frequency of NUDT15 variants but a low frequency of thiopurine S-methyltransferase (TPMT) variants. However, evidence remains limited in populations where both genetic variants are prevalent. This study aimed to characterize the impact of NUDT15 and TPMT polymorphisms on 6-MP-induced hematopoietic toxicity in Thai pediatric patients, a population with a high prevalence of both variants. A total of 215 Thai pediatric patients undergoing maintenance-phase therapy with 6-MP were enrolled. Genotyping for TPMT and NUDT15 was performed, and phenotypes were determined based on the genotype data. The

SUBMITTER: Khaeso K 

PROVIDER: S-EPMC12820576 | biostudies-literature | 2026 Feb

REPOSITORIES: biostudies-literature