Collagen XV preserves heart function and protects from pathological remodelling after myocardial infarction.

ABSTRACT: Increasing knowledge of the components involved in left ventricle (LV) remodelling and fibrotic processes after a myocardial infarction is crucial to understanding heart pathology. We have here analysed collagen XV (ColXV) expression in human myocardial infarct samples and assessed how its deficiency affects cardiac responses, such as fibrogenesis and tissue stiffness, after acute myocardial infarction (AMI) in mice. We first observed high ColXV expression in human infarction scars. After ligating the left anterior descending artery in mice, cardiac function and remodelling were monitored by echocardiography, elasticity assessment, immunohistochemical analysis and ultrastructural assessments. After AMI, Col15a1^-/- mice showed significantly increased tissue stiffness and upregula

SUBMITTER: Karppinen SM 

PROVIDER: S-EPMC12820609 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature