Identifying Therapeutic Targets for Bronchial Asthma: Systematic Druggable Genome-Wide Mendelian Randomization.

ABSTRACT:

Background

The treatment and prevention of bronchial asthma continue to present significant challenges. Mendelian randomization (MR) has been extensively employed to identify novel therapeutic targets. Consequently, we conducted a systematic MR analysis across the druggable genome to identify potential therapeutic targets for asthma.

Aims

Exploring new potential therapeutic targets for the treatment of asthma.

Methods

We obtained data on druggable genes and screened genes within lung expression quantitative trait loci (eQTL) and blood eQTL. Then, MR analysis and colocalization analysis were performed to identify genes highly associated with asthma. In addition, phenome-wide analysis, enrichment analysis and protein-protein interaction network construction (PPI) have b

SUBMITTER: Wang H 

PROVIDER: S-EPMC12820719 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature