Five-Year Absolute Risk-Based and Age-Based Breast Cancer Screening in the US.

ABSTRACT:

Importance

General mammography screening guidelines target women at average risk within a specified age range (age based) and do not consider absolute risk of individual women at a given age (risk based).

Objective

To compare outcomes of mammography screening strategies that vary by 5-year risk of invasive breast cancer vs age-based strategies.

Design, setting, and participants

This decision analytical model used 2 established Cancer Intervention and Surveillance Modeling Network (CISNET) breast cancer models and simulated US women born in 1980 who were aged 40 years or older without a prior history of breast cancer. Modeling analyses were conducted from April 2023 to April 2025.

Intervention

Digital breast tomosynthesis delivered via 50 screening strategies (3

SUBMITTER: Alagoz O 

PROVIDER: S-EPMC12820738 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature