Parental Age and Childhood Allergy Risk.

ABSTRACT:

Importance

Allergic diseases in children are influenced by gene-environment interactions. Although advanced parental age has been associated with genetic and epigenetic changes, its relationship with childhood allergy risk remains unclear.

Objective

To examine the association between parental age at childbirth and the risk of allergic diseases in early childhood.

Design, setting, and participants

This nationwide, multicenter, population-based, prospective birth cohort study used data from the Japan Environment and Children's Study (JECS). Participants were enrolled at 15 regional centers in Japan between January 2011 and March 2014, with follow-up data collected at child ages 1, 2, and 4 years. The present analysis was conducted from July 8, 2024, to February 4, 2025.

SUBMITTER: Yamamoto-Hanada K 

PROVIDER: S-EPMC12820740 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature