Social Defeat Stress Model for Adolescent C57BL/6 Male and Female Mice.

ABSTRACT: Social adversity in adolescence is prevalent and can negatively impact mental health trajectories. Modeling social stress in adolescent male and female rodents is needed to understand its effects on ongoing brain development and behavioral outcomes. The chronic social defeat stress paradigm (CSDS) has been widely used to model social stress in adult C57BL/6 male mice by leveraging on the aggressive behavior displayed by an adult male rodent to an intruder invading its territory. An advantage of this paradigm is that it allows to categorize defeated mice into resilient and susceptible groups based on their individual differences in social behavior 24 h after the last defeat session. Implementing this model in adolescent C57BL/6 mice has been challenging because adult or adolescent mice do n

SUBMITTER: Pantoja-Urban AH 

PROVIDER: S-EPMC12820755 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature