Long-Term Exposure to Air Pollution and Risk and Prognosis of Motor Neuron Disease.

ABSTRACT:

Importance

Air pollution exposure has been associated with an increased risk of neurodegenerative diseases; however, evidence is limited for motor neuron disease (MND), especially regarding disease progression.

Objective

To determine whether long-term exposure to air pollution is associated with the risk and prognosis of MND.

Design, setting, and participants

This population-based, nested case-control study used Swedish health register data of incident MND cases diagnosed between 2015 and 2023 with up to 8 years of follow-up. Participants included patients with MND, 5 age- and sex-matched population controls without MND per patient with MND, and full siblings of the patients with MND. Data were analyzed between November 6, 2024, and November 4, 2025.

Exposures

SUBMITTER: Wu J 

PROVIDER: S-EPMC12820776 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature