Integrative Multiomics Nominate GGCT as a Crucial Regulator of Immunosuppression in Colorectal Cancer.

ABSTRACT: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with tumor microenvironment (TME) heterogeneity playing a critical role in disease progression and therapeutic response. Immune escape (IE) mechanisms facilitate tumor evasion from host immune surveillance, yet their characterization at the single-cell level in CRC is incomplete. This study integrated single-cell RNA sequencing (scRNA-seq) and bulk transcriptomic data from multiple public cohorts to systematically explore IE-related signatures in CRC. We identified major and minor cell populations within the TME and performed differential gene expression analysis. Using high-dimensional weighted gene coexpression network analysis (hdWGCNA), we identified gene modules correlated with IE activity. Subseque

SUBMITTER: Niu Q 

PROVIDER: S-EPMC12820795 | biostudies-literature | 2026

REPOSITORIES: biostudies-literature