Inhibition of GALNT7 suppresses cell proliferation and invasiveness while elevating cell apoptosis via the inactivation of the AKT pathway in non-small cell lung cancer.

ABSTRACT:

Objective

Polypeptide N-acetylgalactosaminyltransferase 7 (GALNT7) is a glycopeptide transferase which is closely involved in the development and progression of cancer. This study aimed to investigate the effects of GALNT7 inhibition on non-small cell lung cancer (NSCLC) cell proliferation, apoptosis and invasiveness and to determine whether these effects are mediated by the protein kinase B (AKT) pathway.

Methods

Negative control small interfering RNA (siRNA) (si-NC) and siRNA targeting GALNT7 (si-GALNT7) were transfected into A549 and NCI-H1650 cells. Afterwards, the AKT activator '740 Y-P' was added to treat the cells with or without siRNA transfection.

Results

Cell proliferation was reduced after si-GALNT7 transfection compared with si-NC transfection at 24 hours,

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12820836 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature