Patterns of spinal new bone formation in patients with axial spondyloarthritis, psoriatic arthritis, rheumatoid arthritis and healthy controls: a low-dose CT study.

ABSTRACT:

Objective

This study (the SpACT study) aimed to investigate the frequency and localisations of different types of spinal new bone formation (NBF) in patients with axial spondyloarthritis (axSpA), psoriatic arthritis (PsA), rheumatoid arthritis (RA) and healthy controls (HCs) using low-dose CT (ldCT).

Methods

Patients with axSpA, PsA or RA, and HC without a history of chronic back pain were included and underwent ldCT of the entire spine. Three readers blinded to all clinical information, including diagnosis, assessed sagittal and coronal images for NBF: (1) marginal syndesmophytes, (2) non-marginal syndesmophytes and (3) osteophytes.

Results

69 participants (33 females, mean age 51.4 years) were included: AxSpA: 30; PsA: 19; RA: 10; HC: 10. Across all groups, the thor

SUBMITTER: Willesen ST 

PROVIDER: S-EPMC12820849 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature