Acute kidney injury due to diarrhoeal diseases in children: a systematic review.

ABSTRACT:

Introduction

Acute kidney injury (AKI) is a major health concern, disproportionately affecting children in low- and lower-middle-income countries (LLMICs). Diarrhoeal diseases, a leading cause of paediatric morbidity and mortality, are significant contributors to AKI.

Methods

This study systematically reviewed literature published post-2000 on three groups of children: those hospitalised with diarrhoea who developed AKI (Diarrhoea/AKI), those hospitalised with AKI attributable to diarrhoea (AKI/Diarrhoea), and those with diarrhoea-associated haemolytic uraemic syndrome (D⁺-HUS).

Results

After screening 1895 titles and abstracts, 92 studies were included. Most focused on D⁺-HUS (76%), with fewer addressing AKI/Diarrhoea (15%) and Diarrhoea/AKI (9%

SUBMITTER: Merz LM 

PROVIDER: S-EPMC12820867 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature