ANGPTL8 is upregulated in subcutaneous adipose tissue at early term after bariatric surgery in patients living with obesity.

ABSTRACT:

Objective

Our aim is to study proteomic and transcriptomic changes in the subcutaneous white adipose tissue (sWAT) from patients living with severe obesity at early term after bariatric surgery (BS).

Methods

Twenty-two sWAT biopsies were collected at the time of surgery and 3 months afterward (11 for each point and from the same patient). Clinical data and metabolic parameters were measured. Targeted proteomic profiling and RNA sequencing were conducted. Bioinformatic analyses were performed to identify differentially expressed proteins and genes and their associated pathways.

Results

Early-term after BS leads to significant reductions in some clinical parameters. Twenty inflammatory proteins, including cytokines, chemokines and immune-regulatory factors were increase

SUBMITTER: Negro EM 

PROVIDER: S-EPMC12820915 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature