Host-Guest Complexes of Cyclopentadienyl Iron Dicarbonyl (CpFe(CO)₂) CO-Releasing Molecules with Cucurbit[7]uril.

ABSTRACT: Iron-(II) cyclopentadienyl carbonyl complexes are promising as CO-releasing molecules (CORMs) for therapeutic applications. In common with other metallodrugs, the practical application of Fe-CORMs may require their conjugation with biocompatible carriers to improve their bioavailability and protect them from premature degradation. Here, we show that the CO-releasing properties of the complexes [CpFe-(CO)₂Cl] (1) and [CpFe-(CO)₂CH₂CONH₂] (2) are retained when noncovalently encapsulated within cucurbit[7]-uril (CB7), a well-established drug-enhancing excipient. The inclusion compounds were characterized in the solid-state by single-crystal and powder XRD, ATR-IR spectroscopy, Raman spectroscopy, TGA, and ¹³C-{¹H}

SUBMITTER: Monteiro RP 

PROVIDER: S-EPMC12820945 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature