High Cytotoxicity of Ruthenium(II) and Gold(I) Bimetallic Complexes and Its Precursors.

ABSTRACT: A series of Ru(II)-PC_(n)P-Au(I) (n = 1-5) bimetallic complexes were successfully synthesized and characterized with phosphorus (³¹P{H}) and proton (¹H) nuclear magnetic resonance (NMR) spectroscopy, electrospray ionization mass spectrometry (ESI-MS), supported by crystallographic data. Correlations between resonance shifts and P-Au(I) bond distances provided insight into the electronic environment of the phosphorus centers, while single-crystal X-ray diffraction confirmed the molecular structures. Hirshfeld surface analysis revealed dominant H···H and F···H/H···F interactions, with contact percentages varying systematically with carbon chain length. Biological evaluation showed that the complexes exhibited higher cytotoxicity than cisplatin an

SUBMITTER: Blignaut J 

PROVIDER: S-EPMC12820967 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature