An Injectable Hybrid Gelatin Methacryloyl/Polydopamine Nanoparticle Bioink for Rapid Hemostasis Applications.

ABSTRACT: Uncontrolled hemorrhage is frequently associated with high mortality. To address this challenge, engineered hydrogels have been widely investigated for hemorrhage control because of their fluid absorption and ability to promote blood coagulation. In this study, we developed injectable bioinks by combining gelatin methacryloyl (GelMA) with polydopamine (PDA) nanoparticles of various sizes. PDA nanoparticles provided abundant surface catechol groups and negative charges. We showed that GelMA hydrogels containing PDA nanoparticles smaller than 600 nm exhibited uniform porous networks. These hydrogels possessed >60% porosity and more than a 6-fold higher swelling capacity than pure GelMA hydrogels. These properties reduced blood clotting time by 2.6-fold, facilitated rapid blood absorption, an

SUBMITTER: Fan SM 

PROVIDER: S-EPMC12820968 | biostudies-literature | 2026 Jan

REPOSITORIES: biostudies-literature